Interfacial and biological properties of the gradient coating on polyamide substrate for bone substitute.

نویسندگان

  • Di Huang
  • Lulu Niu
  • Yan Wei
  • Meiqing Guo
  • Yi Zuo
  • Qin Zou
  • Yinchun Hu
  • Weiyi Chen
  • Yubao Li
چکیده

Fabrication of bioactive and mechanical matched bone substitutes is crucial for clinical application in bone defects repair. In this study, nano-hydroxyapatite/polyamide (nHA/PA) composite was coated on injection-moulded PA by a chemical corrosion and phase-inversion technique. The shear strength, gradient composition and pore structure of the bioactive coating were characterized. Osteoblast-like MG63 cells were cultured on pure PA and composite-coated PA samples. The cells' adhesion, spread and proliferation were determined using MTT assay and microscopy. The results confirm that the samples with the nHA/PA composite coating have better cytocompatibility and have no negative effects on cells. To investigate the in vivo biocompatibility, both pure PA and composite-coated PA cylinders were implanted in the trochlea of rabbit femurs and studied histologically, and the bonding ability with bone were determined using push-out tests. The results show that composite-coated implants exhibit better biocompatibility and the shear strength of the composite-coated implants with host bone at 12 weeks can reach 3.49±0.42 MPa, which is significantly higher than that of pure PA implants. These results indicate that composite-coated PA implants have excellent biocompatibility and bonding abilities with host bone and they have the potential to be applied in repair of bone defects.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

نقش پوشش های بیوسرامیکی در موفقیت ایمپلنت ها

Characterization of bioceramics coating and evaluation of the influence of kind of coating on the implantation has been developed in recent years.Different bioceramics coating like calcium phosphate, hydroxyapatite, fluorapatite and bioglass were coated on dental and orthopedic implants. In-vitro and in-vivo experiments were done for evolution of implant success and reliability and study of fac...

متن کامل

Effect of Fiber Surface Treatment on Wear Characteristics of Carbon Fiber Reinforced Polyamide 6 Composites

Ozone modification method and air-oxidation were used for the surface treatment of polyacrylonitrile(PAN)-based carbon fiber. The surface characteristics of carbon fibers were characterized by X-ray photoelectron spectroscopy (XPS). The interfacial properties of carbon fiber reinforced polyamide 6 (CF/PA6) composites were investigated by means of the single fiber pull-out tests. As a result...

متن کامل

Electrodeposition of Nano Hydroxyapatite Coating on Biodegradable Mg-Zn Scaffold (TECHNICAL NOTE)

Magnesium has been recently recognized as a biodegradation metal for bone substitute application. In the present work, porous magnesium-zinc scaffolds were prepared by powder metallurgical process and nano hydroxyapatite (HAP) coating on the Mg-3Zn (wt.%) scaffold was prepared by pulse electrodeposition and alkali treatment processes to improve the corrosion resistance of scaffold. The results ...

متن کامل

Investigation of the electrical properties and corrosion resistance of TiN coating deposited by reactive sputtering on the titanium bipolar plate, used in polymeric fuel cell

The effect of titanium nitride film on the properties of titanium bipolar plates used in polymeric fuel cell was investigated in this research. TiN coatings was deposited on the Ti-grade 1 substrate by using DC-sputtering method. Pure titanium was used as target and coating deposition was done in argon and nitrogen atmosphere. Different TiN thickness was developed by changing sputtering time. T...

متن کامل

Fabrication of functionally graded Ni-Al2O3 nanocomposite coating and evaluation of its properties

In this study, functionally graded Ni-Al2O3 composite coating (FGN-A) has been produced from nickel Watt’s bath containing different concentrations of Al2O3 particles. For this, different composite coatings were electroplated in the same bath with different particles concentration to find the optimum concentration of particles in which the maximum content with uniform distribution of Al2O3 part...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of the Royal Society, Interface

دوره 11 99  شماره 

صفحات  -

تاریخ انتشار 2014